Поле DC | Значение | Язык |
dc.contributor.author | Dovgan, A. P. | - |
dc.date.accessioned | 2022-04-28T05:10:29Z | - |
dc.date.available | 2022-04-28T05:10:29Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Dovgan, A.P. Ligand of peripheral imidazoline receptors based on amides of heterocyclic acids C7070: effect on ishemized tissues / A.P. Dovgan // Research result. Pharmacology and clinical pharmacology. - 2017. - Vol. 3, № 4.- P. 78-88. - Doi: 10.18413/2313-8971-2017-3-4-78-88. - Refer.: p. 85-88. | ru |
dc.identifier.uri | http://dspace.bsu.edu.ru/handle/123456789/46435 | - |
dc.description.abstract | In this regard, the study of pleiotropic hepatoprotective properties of the agonist of peripheral imidazoline receptors C7070 seems interesting from an applied point of view. Models of a skin flap on a feeding leg, ischemia-reperfusion of the liver and rat heart isolated from Langendorff (ischemia-reperfusion and doxorubicin cardiomyopathy) were used. The I2 agonist C7070 at a dose of 10 mg/kg 4.5-fold prevents the increase in ALT and AST (332.56 ± 22.05/825.49 ± 22.46 ALT/AST 526.90 ± 17.97/1045.16 ± 80.02 units/l in control) and 2.5 times reduces the areas of ischmeic damage and necrosis (0.058 ± 0.029/0.046 ± 0.013 mm2) in the modeling of 15-minute ischemia liver. Moxonidine and metformin had a hepatoprotective effect: 44.99 and 36.88 for moxonidine (ALT and AST) and 34.20 / 21.02 for metformin (ALT / AST). The coefficients of histological hepatoprotective activity: 72.33 and 38.96 (moxonidine and metformin) | ru |
dc.language.iso | en | ru |
dc.subject | medicine | ru |
dc.subject | pharmacology | ru |
dc.subject | biology | ru |
dc.subject | zoology | ru |
dc.subject | physiology of animals | ru |
dc.subject | С7070 | ru |
dc.subject | metformin | ru |
dc.subject | moxonidine | ru |
dc.subject | ischemia | ru |
dc.subject | reperfusion | ru |
dc.subject | liver | ru |
dc.subject | skin flap | ru |
dc.subject | isolated heart | ru |
dc.subject | according to Langendorf | ru |
dc.title | Ligand of peripheral imidazoline receptors based on amides of heterocyclic acids C7070: effect on ishemized tissues | ru |
dc.type | Article | ru |
Располагается в коллекциях: | Vol. 3, № 4
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