Hypoxia-inducible factor: basic biology and involvement in cardiovascular pathology

Abstract

Molecular epidemiological studies conducted to date reveal a close relationship between the polymorphism of the HIF system genes with a wide range of cardiovascular, inflammatory, and oncological diseases. The study of the HIF system can contribute to the discovery of new targets and methods of pharmacological effects for the treatment of cardiovascular, oncological, rheumatological, and endocrinological pathology